The Role of Genetic and Epigenetic Factors in Polycystic Ovary Syndrome (PCOS) Development and Treatment Outcomes

Samenvatting

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder affecting a significant proportion of women of reproductive age worldwide. While the pathophysiology of PCOS is not fully understood, genetic predispositions and epigenetic modifications have emerged as influential factors in its development and progression. This study investigates the relationship between genetic and epigenetic markers, specifically DNA methylation levels, and lifestyle factors such as diet, exercise, and stress in PCOS patients. Utilizing a sample of 300 patients, we conducted quantitative and multivariate analyses to explore the impact of these variables on body mass index (BMI) as a key indicator of PCOS severity. The findings indicate a significant negative association between DNA methylation levels and BMI, suggesting that higher methylation may offer protective effects against weight gain, a common PCOS symptom. While age and stress levels showed no statistically significant impact on BMI, the study highlights the potential of personalized medicine in PCOS management by considering genetic and epigenetic profiles. These results underscore the importance of integrating molecular insights with lifestyle interventions to improve PCOS treatment outcomes. Future research should focus on larger samples and a broader range of biomarkers to deepen our understanding of the complex interactions underlying PCOS.